The Metabolic Response to Iron Deficiency in Saccharomyces Cerevisiae
نویسندگان
چکیده
THE METABOLIC RESPONSE TO IRON DEFICIENCY IN SACCHAROMYCES CEREVISIAE. Minoo Shakoury-Elizeh, Olga Protchenko, Alvin Berger, James Cox, Kenneth Gable, Teresa M. Dunn, William A. Prinz, Martin Bard, and Caroline C. Philpott Liver Diseases Branch and Laboratory of Cell Biology and Biochemistry, NIDDK, NIH, Metabolon, Inc., 800 Capitola Drive, Suite 1, Durham, NC Metabolomics Core Research Facility, University of Utah, Salt Lake City, UT Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN Running title: Metabolomics of iron deficiency in yeast Corresponding author: Caroline C. Philpott, Bldg 10, Rm 9B-16, 10 Center Drive, Bethesda, MD, 20892, Phone: 301-435-4018, Fax: 301-402-0491, E-mail: [email protected]
منابع مشابه
Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins.
Saccharomyces cerevisiae (baker's yeast) is an excellent model for understanding fundamental biological mechanisms that are conserved in Nature and that have an impact on human disease. The metal iron is a redox-active cofactor that plays critical biochemical roles in a broad range of functions, including oxygen transport, mitochondrial oxidative phosphorylation, chromatin remodelling, intermed...
متن کاملResponse to iron deprivation in Saccharomyces cerevisiae.
Iron is an essential nutrient for almost every organism because iron cofactors, such as heme and iron-sulfur clusters (ISC), are required for the activity of numerous cellular enzymes involved in a wide range of cellular processes. Although iron is a very abundant metal in the earth’s crust, it has a low bioavailability. In aerobic environments, iron is largely present in the oxidized, ferric f...
متن کاملProduction of vitamin D3 enriched biomass of Saccharomyces cerevisiae as a potential food supplement: evaluation and optimization of culture conditions using Plackett–Burman and response surface methodological approaches
Vitamin D deficiency causes osteoporosis, osteopenia, fractures, rickets and more recently is linked with some chronic illnesses such as cancer. Because of the safety and probiotic properties of the yeast Saccharomyces cerevisiae, we hypothesized that yeast cells enriched with cholecalciferol (vitamin D3) could represent a solution for prevention or treatment of vitamin D deficiency. In this st...
متن کاملProduction of vitamin D3 enriched biomass of Saccharomyces cerevisiae as a potential food supplement: evaluation and optimization of culture conditions using Plackett–Burman and response surface methodological approaches
Vitamin D deficiency causes osteoporosis, osteopenia, fractures, rickets and more recently is linked with some chronic illnesses such as cancer. Because of the safety and probiotic properties of the yeast Saccharomyces cerevisiae, we hypothesized that yeast cells enriched with cholecalciferol (vitamin D3) could represent a solution for prevention or treatment of vitamin D deficiency. In this st...
متن کاملCharacterization of an Interesting Novel Mutant Strain of Commercial Saccharomyces cerevisiae
The yeast strains that are resistant to high concentration of ethanol have biotechnological benefits and aresuitable models for physiology and molecular genetics research fields. A novel ethanol-tolerant mutant strain,mut1, derived from the commercial Saccharomyces cerevisiae showed higher ethanol production, and alsodemonstrated resistance to ethanol but not to other alcohols...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010